Porphyrin derivative nanoformulations for therapy and antiparasitic agents

DK Deda, BA Iglesias, E Alves, K Araki, CRS Garcia - Molecules, 2020 - mdpi.com
Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and
luminescence properties demonstrating high potential in the treatment of several diseases …

Babesia, Theileria, Plasmodium and hemoglobin

D Sojka, M Jalovecká, J Perner - Microorganisms, 2022 - mdpi.com
The Propagation of Plasmodium spp. and Babesia/Theileria spp. vertebrate blood stages
relies on the mediated acquisition of nutrients available within the host's red blood cell …

Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity

ACC Aguiar, M Panciera… - Journal of medicinal …, 2018 - ACS Publications
We report the discovery of marinoquinoline (3 H-pyrrolo [2, 3-c] quinoline) derivatives as
new chemotypes with antiplasmodial activity. We evaluated their inhibitory activities against …

New molecular targets and strategies for antimalarial discovery

AC Aguiar, LRF de Sousa, CRS Garcia… - Current Medicinal …, 2019 - ingentaconnect.com
Malaria remains a major health problem, especially because of the emergence of resistant
P. falciparum strains to artemisinin derivatives. In this context, safe and affordable …

Plasmodium falciparum Knockout for the GPCR-Like PfSR25 Receptor Displays Greater Susceptibility to 1,2,3-Triazole Compounds That Block Malaria Parasite …

BM Santos, DTG Gonzaga, FC da Silva, VF Ferreira… - Biomolecules, 2020 - mdpi.com
The search for new compounds with antimalarial activity is urgent, as resistance to ones in
the classical drug, has already been described in more than one continent. Compounds …

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

AH Lee, SK Dhingra, IA Lewis, MK Singh… - Scientific reports, 2018 - nature.com
Plasmodium falciparum multidrug resistance constitutes a major obstacle to the global
malaria elimination campaign. Specific mutations in the Plasmodium falciparum chloroquine …

Multiple origins of green blood in New Guinea lizards

ZB Rodriguez, SL Perkins, CC Austin - Science Advances, 2018 - science.org
Several species of lizards from the megadiverse island of New Guinea have evolved green
blood. An unusually high concentration of the green bile pigment biliverdin in the circulatory …

Untargeted metabolomics to discriminate liver and lung hydatid cysts: Importance of metabolites involved in the immune response

M Nenni, M Çelebier, S Maçin, S Örsten… - Veterinary …, 2024 - Elsevier
The Echinococcus granulosus sensu lato species complex is responsible for the neglected
zoonotic disease known as cystic echinococcosis (CE). Humans and livestock are infected …

Evidences of G coupled-protein receptor (GPCR) signaling in the human malaria parasite Plasmodium falciparum for sensing its microenvironment and the role of …

PHS Pereira, L Borges-Pereira… - Current Topics in …, 2021 - ingentaconnect.com
The nucleotides were discovered in the early 19th century and a few years later, the role of
such molecules in energy metabolism and cell survival was postulated. In 1972, a pioneer …

Complete Molecular and Immunoprotective Characterization of Babesia microti Enolase

X Liu, C Zheng, X Gao, J Chen, K Zheng - Frontiers in Microbiology, 2017 - frontiersin.org
The apicomplexan Babesia microti is the primary causative agent of human babesiosis, one
of the most broadly distributed tick-borne diseases worldwide. B. microti undergoes a …