Porphyrin derivative nanoformulations for therapy and antiparasitic agents
Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and
luminescence properties demonstrating high potential in the treatment of several diseases …
luminescence properties demonstrating high potential in the treatment of several diseases …
Babesia, Theileria, Plasmodium and hemoglobin
The Propagation of Plasmodium spp. and Babesia/Theileria spp. vertebrate blood stages
relies on the mediated acquisition of nutrients available within the host's red blood cell …
relies on the mediated acquisition of nutrients available within the host's red blood cell …
Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity
ACC Aguiar, M Panciera… - Journal of medicinal …, 2018 - ACS Publications
We report the discovery of marinoquinoline (3 H-pyrrolo [2, 3-c] quinoline) derivatives as
new chemotypes with antiplasmodial activity. We evaluated their inhibitory activities against …
new chemotypes with antiplasmodial activity. We evaluated their inhibitory activities against …
New molecular targets and strategies for antimalarial discovery
Malaria remains a major health problem, especially because of the emergence of resistant
P. falciparum strains to artemisinin derivatives. In this context, safe and affordable …
P. falciparum strains to artemisinin derivatives. In this context, safe and affordable …
Plasmodium falciparum Knockout for the GPCR-Like PfSR25 Receptor Displays Greater Susceptibility to 1,2,3-Triazole Compounds That Block Malaria Parasite …
The search for new compounds with antimalarial activity is urgent, as resistance to ones in
the classical drug, has already been described in more than one continent. Compounds …
the classical drug, has already been described in more than one continent. Compounds …
Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter
Plasmodium falciparum multidrug resistance constitutes a major obstacle to the global
malaria elimination campaign. Specific mutations in the Plasmodium falciparum chloroquine …
malaria elimination campaign. Specific mutations in the Plasmodium falciparum chloroquine …
Multiple origins of green blood in New Guinea lizards
Several species of lizards from the megadiverse island of New Guinea have evolved green
blood. An unusually high concentration of the green bile pigment biliverdin in the circulatory …
blood. An unusually high concentration of the green bile pigment biliverdin in the circulatory …
Untargeted metabolomics to discriminate liver and lung hydatid cysts: Importance of metabolites involved in the immune response
The Echinococcus granulosus sensu lato species complex is responsible for the neglected
zoonotic disease known as cystic echinococcosis (CE). Humans and livestock are infected …
zoonotic disease known as cystic echinococcosis (CE). Humans and livestock are infected …
Evidences of G coupled-protein receptor (GPCR) signaling in the human malaria parasite Plasmodium falciparum for sensing its microenvironment and the role of …
PHS Pereira, L Borges-Pereira… - Current Topics in …, 2021 - ingentaconnect.com
The nucleotides were discovered in the early 19th century and a few years later, the role of
such molecules in energy metabolism and cell survival was postulated. In 1972, a pioneer …
such molecules in energy metabolism and cell survival was postulated. In 1972, a pioneer …
Complete Molecular and Immunoprotective Characterization of Babesia microti Enolase
X Liu, C Zheng, X Gao, J Chen, K Zheng - Frontiers in Microbiology, 2017 - frontiersin.org
The apicomplexan Babesia microti is the primary causative agent of human babesiosis, one
of the most broadly distributed tick-borne diseases worldwide. B. microti undergoes a …
of the most broadly distributed tick-borne diseases worldwide. B. microti undergoes a …