Neuroblastoma: When differentiation goes awry
Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …
Time to go: neural crest cell epithelial-to-mesenchymal transition
Neural crest cells (NCCs) are a dynamic, multipotent, vertebrate-specific population of
embryonic stem cells. These ectodermally-derived cells contribute to diverse tissue types in …
embryonic stem cells. These ectodermally-derived cells contribute to diverse tissue types in …
A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells
K Murakami, Y Terakado, K Saito… - Proceedings of the …, 2021 - National Acad Sciences
An ability to safely harness the powerful regenerative potential of adult stem cells for clinical
applications is critically dependent on a comprehensive understanding of the underlying …
applications is critically dependent on a comprehensive understanding of the underlying …
Cranial neural crest cells and their role in the pathogenesis of craniofacial anomalies and coronal craniosynostosis
Craniofacial anomalies are among the most common of birth defects. The pathogenesis of
craniofacial anomalies frequently involves defects in the migration, proliferation, and fate of …
craniofacial anomalies frequently involves defects in the migration, proliferation, and fate of …
[HTML][HTML] Integrating chemical and mechanical signals in neural crest cell migration
Neural crest cells are a multipotent embryonic stem cell population that migrate large
distances to contribute a variety of tissues. The cranial neural crest, which contribute to …
distances to contribute a variety of tissues. The cranial neural crest, which contribute to …
[HTML][HTML] The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro …
M Sachana, C Willett, F Pistollato, A Bal-Price - Reproductive Toxicology, 2021 - Elsevier
A major challenge in regulatory developmental neurotoxicity (DNT) assessment is lack of
toxicological information for many compounds. Therefore, the Test Guidelines programme of …
toxicological information for many compounds. Therefore, the Test Guidelines programme of …
Wnt-activating human skin organoid model of atopic dermatitis induced by Staphylococcus aureus and its protective effects by Cutibacterium acnes
S Jung, HJ You, MJ Kim, GP Ko, S Lee, KS Kang - Iscience, 2022 - cell.com
A recently developed human PSC-derived skin organoid model has opened up new
avenues for studying skin development, diseases, and regeneration. The current model has …
avenues for studying skin development, diseases, and regeneration. The current model has …
In vivo Neural Crest Cell Migration Is Controlled by “Mixotaxis”
EH Barriga, E Theveneau - Frontiers in physiology, 2020 - frontiersin.org
Directed cell migration is essential all along an individual's life, from embryogenesis to
tissue repair and cancer metastasis. Thus, due to its biomedical relevance, directed cell …
tissue repair and cancer metastasis. Thus, due to its biomedical relevance, directed cell …
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors
LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part,
through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of …
through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of …
Potential of rosmarinic acid from Orthosiphon aristatus extract for inflammatory induced diseases and its mechanisms of action
Orthosiphon aristatus has been traditionally used as a medicinal herb for various illnesses in
Southeast Asia and Europe. The most dominant bioactive compound of the herb is …
Southeast Asia and Europe. The most dominant bioactive compound of the herb is …