Quantitative dynamics of paradigmatic SN2 reaction OH−+ CH3F on accurate full-dimensional potential energy surface

J Qin, Y Liu, J Li - The Journal of Chemical Physics, 2022 - pubs.aip.org
The bimolecular reaction between OH− and CH 3 F is not just a prototypical SN 2 process,
but it has three other product channels. Here, we develop an accurate full-dimensional …

Local and linear chemical reactivity response functions at finite temperature in density functional theory

M Franco-Pérez, PW Ayers, JL Gázquez… - The Journal of chemical …, 2015 - pubs.aip.org
We explore the local and nonlocal response functions of the grand canonical potential
density functional at nonzero temperature. In analogy to the zero-temperature treatment …

An interacting quantum atom study of model SN2 reactions (X···CH3X, X = F, Cl, Br, and I)

I Alkorta, JCR Thacker… - Journal of Computational …, 2018 - Wiley Online Library
The quantum chemical topology method has been used to analyze the energetic profiles in
the X–+ CH3X→ XCH3+ X–SN2 reactions, with X= F, Cl, Br, and I. The evolution of the …

Energetic descriptors of steric hindrance in real space: an improved IQA picture

M Gallegos, A Costales, AM Pendas - ChemPhysChem, 2021 - Wiley Online Library
Steric hindrance (SH) plays a central role in the modern chemical narrative, lying at the core
of chemical intuition. As it however happens with many successful chemical concepts, SH …

Does steric hindrance actually govern the competition between bimolecular substitution and elimination reactions?

M Gallegos, A Costales… - The Journal of Physical …, 2022 - ACS Publications
Bimolecular nucleophilic substitution (SN2) and elimination (E2) reactions are prototypical
examples of competing reaction mechanisms, with fundamental implications in modern …

Curly arrows, electron flow, and reaction mechanisms from the perspective of the bonding evolution theory

J Andrés, P González-Navarrete, VS Safont… - Physical Chemistry …, 2017 - pubs.rsc.org
Despite the usefulness of curly arrows in chemistry, their relationship with real electron
density flows is still imprecise, and even their direct connection to quantum chemistry is still …

ElectroPredictor: An Application to Predict Mayr's Electrophilicity E through Implementation of an Ensemble Model Based on Machine Learning Algorithms

SA Cuesta, M Moreno, RA López, JR Mora… - Journal of Chemical …, 2023 - ACS Publications
Electrophilicity (E) is one of the most important parameters to understand the reactivity of an
organic molecule. Although the theoretical electrophilicity index (ω) has been associated …

Atomic decomposition of conceptual DFT descriptors: application to proton transfer reactions

R Inostroza-Rivera, M Yahia-Ouahmed… - Physical Chemistry …, 2015 - pubs.rsc.org
In this study, we present an atomic decomposition, in principle exact, at any point on a given
reaction path, of the molecular energy, reaction force and reaction flux, which is based on …

How Does Electronic Activity Drive Chemical Reactions? Insights from the Reaction Electronic Flux for the Conversion of Dopamine into Norepinephrine

AC Forero-Girón, A Toro-Labbé - The Journal of Physical …, 2022 - ACS Publications
Hydrogen atom transfer (HAT) is a crucial step in the physiological conversion of dopamine
into norepinephrine catalyzed by dopamine β-monooxygenase. The way the reaction takes …

The mechanism of chemisorption of hydrogen atom on graphene: Insights from the reaction force and reaction electronic flux

D Cortes-Arriagada, S Gutierrez-Oliva… - The Journal of …, 2014 - pubs.aip.org
At the PBE-D3/cc-pVDZ level of theory, the hydrogen chemisorption on graphene was
analyzed using the reaction force and reaction electronic flux (REF) theories in combination …