abstract Atopic dermatitis (AD) is a heterogenous disorder and can be classified into
different types. Stratification of subtypes may enable personalized medicine approaches. AD …

Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …

Objective To provide an overview of filaggrin biology and the role of filaggrin variants in
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …

Abstract Background African Americans (AA) are disproportionately impacted by atopic
dermatitis (AD), with increased prevalence and therapeutic challenges unique to this …

Background: Atopic dermatitis is a common inflammatory skin disorder that affects up to 15–
20% of the population and is characterized by recurrent eczematous lesions with intense …

Atopic dermatitis (AD) is the most common inflammatory skin disease worldwide, affecting
20% of children and 5% of adults. One critical component in the pathophysiology of AD is …

Background A genetic defect in the epidermal barrier protein filaggrin (FLG) plays a major
role in the etiology of eczema and associated allergic airways diseases. However, it is still …

Background Diet diversity (DD) during infancy may prevent food allergies (FA), possibly by
exposing the gastrointestinal microbiota to diverse foods and nutrients. Objective To …

Loss-of-function (LoF) variants in the filaggrin (FLG) gene are the strongest known genetic
risk factor for atopic dermatitis (AD), but the impact of these variants on AD outcomes is …