Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic
functions, including protein degradation, nucleic acid modification, and many others. Given …

Fragment-based drug discovery (FBDD) is a powerful strategy for the identification of new
bioactive molecules. FBDD relies on fragment libraries, generally of modest size, but of high …

Tyrosinases are copper-containing metalloenzymes involved in several processes in both
mammals, insects, bacteria, fungi and plants. Their phenol oxidation properties are …

Enzymes are common targets in high-throughput screening and related campaigns. An
analysis of papers published between 1990 and 2018 showed that kinases were the most …

Fragment-based drug discovery (FBDD) has grown and matured to a point where it is
valuable to keep track of its extent and details of application. This Perspective summarizes …

The self-splicing group II introns are bacterial and organellar ancestors of the nuclear
spliceosome and retro-transposable elements of pharmacological and biotechnological …

Significant efforts have been reported on the development of influenza antivirals including
inhibitors of the RNA-dependent RNA polymerase PA N-terminal (PAN) endonuclease …

Ethyl maltol is one of the most important aromatic components in food and cigarettes
because of its caramel flavour. However, the development of ethyl maltol is limited by …

Hydrolysis of β-lactam drugs, a major class of antibiotics, by serine or metallo-β-lactamases
(SBL or MBL) is one of the main mechanisms for antibiotic resistance. New Delhi Metallo-β …

UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a zinc metalloenzyme that
catalyzes the first committed step in the biosynthesis of Lipid A, an essential component of …