Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023‏ - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Myosteatosis in the context of skeletal muscle function deficit: an interdisciplinary workshop at the National Institute on Aging

R Correa-de-Araujo, O Addison, I Miljkovic… - Frontiers in …, 2020‏ - frontiersin.org
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases
with aging and is recognized to negatively correlate with muscle mass, strength, and mobility …

Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans

L Talamanca, C Gobet, F Naef - Science, 2023‏ - science.org
The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …

[HTML][HTML] Lipid metabolism around the body clocks

V Petrenko, F Sinturel, H Riezman, C Dibner - Progress in Lipid Research, 2023‏ - Elsevier
Lipids play important roles in energy metabolism along with diverse aspects of biological
membrane structure, signaling and other functions. Perturbations of lipid metabolism are …

Circadian rhythms and exercise—re-setting the clock in metabolic disease

BM Gabriel, JR Zierath - Nature Reviews Endocrinology, 2019‏ - nature.com
Perturbed diurnal rhythms are becoming increasingly evident as deleterious events in the
pathology of metabolic diseases. Exercise is well characterized as a crucial intervention in …

Chrono‐nutrition: from molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

A Flanagan, DA Bechtold, GK Pot… - Journal of …, 2021‏ - Wiley Online Library
The circadian timing system governs daily biological rhythms, synchronising physiology and
behaviour to the temporal world. External time cues, including the light‐dark cycle and …

Metabolism and exercise: the skeletal muscle clock takes centre stage

RA Martin, MR Viggars, KA Esser - Nature Reviews Endocrinology, 2023‏ - nature.com
Circadian rhythms that influence mammalian homeostasis and overall health have received
increasing interest over the past two decades. The molecular clock, which is present in …

Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis

S Sato, AL Basse, M Schönke, S Chen, M Samad… - Cell metabolism, 2019‏ - cell.com
While the timing of food intake is important, it is unclear whether the effects of exercise on
energy metabolism are restricted to unique time windows. As circadian regulation is key to …

A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults

I Templeman, HA Smith, E Chowdhury… - Science translational …, 2021‏ - science.org
Intermittent fasting may impart metabolic benefits independent of energy balance by
initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour …

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

LS Lundell, EB Parr, BL Devlin, LR Ingerslev… - Nature …, 2020‏ - nature.com
Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient
composition or energy restriction. To elucidate mechanisms underpinning the effects of short …