Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …

The degeneration of light-detecting rod and cone photoreceptors in the human retina leads
to severe visual impairment and ultimately legal blindness in millions of people worldwide …

Human retinal organoids from induced pluripotent stem cells (hiPSCs) can be used to
confirm the localization of proteins in retinal cell types and to test transduction and …

The majority of patients with mutations in CRB1 develop either early-onset retinitis
pigmentosa as young children or Leber congenital amaurosis as newborns. The cause for …

Human induced pluripotent stem cells (hiPSCs) promise a great number of future
applications to investigate retinal development, pathophysiology and cell therapies for …

Age-related macular degeneration (AMD) is a growing public health concern given the
aging population and it is the leading cause of blindness in developed countries, affecting …

Early in vivo embryonic retinal development is a well-documented and evolutionary
conserved process. The specification towards eye development is temporally controlled by …

Angiotensin-converting enzyme 2 (ACE2) was identified as the main host cell receptor for
the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its …

The Crumbs complex has prominent roles in the control of apical cell polarity, in the coupling
of cell density sensing to downstream cell signaling pathways, and in regulating junctional …

Optogenetic technologies paved the way to dissect complex neural circuits and monitor
neural activity using light in animals. In retinal disease, optogenetics has been used as a …