SigCom LINCS: data and metadata search engine for a million gene expression signatures

JE Evangelista, DJB Clarke, Z ** from nucleosome profiling of cell-free DNA
AL Doebley, M Ko, H Liao, AE Cruikshank… - Nature …, 2022 - nature.com
Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help
guide clinical precision oncology. Here we develop Griffin, a framework for profiling …

The effects of caloric restriction on adipose tissue and metabolic health are sex-and age-dependent

KJ Suchacki, BJ Thomas, YM Ikushima, KC Chen… - Elife, 2023 - elifesciences.org
Caloric restriction (CR) reduces the risk of age-related diseases in numerous species,
including humans. CR's metabolic effects, including decreased adiposity and improved …

Anti–miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response

MP Dragomir, E Fuentes-Mattei, M Winkle… - The Journal of Clinical …, 2023 - jci.org
Sepsis remains a leading cause of death for humans and currently has no pathogenesis-
specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic …

Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer …

DC Rigiracciolo, N Nohata, R Lappano, F Cirillo… - Journal of Experimental …, 2022 - Springer
Background Understanding the intricate signaling network involved in triple-negative breast
cancer (TNBC) represents a challenge for develo** novel therapeutic approaches. Here …

DNA methylation-based classifier differentiates intrahepatic pancreato-biliary tumours

MP Dragomir, TG Calina, E Perez, S Schallenberg… - …, 2023 - thelancet.com
Background Differentiating intrahepatic cholangiocarcinomas (iCCA) from hepatic
metastases of pancreatic ductal adenocarcinoma (PAAD) is challenging. Both tumours have …