Environmental enteric dysfunction pathways and child stunting: A systematic review

KM Harper, M Mutasa, AJ Prendergast… - PLoS neglected …, 2018 - journals.plos.org
Background Environmental enteric dysfunction (EED) is commonly defined as an acquired
subclinical disorder of the small intestine, characterized by villous atrophy and crypt …

Preventing environmental enteric dysfunction through improved water, sanitation and hygiene: an opportunity for stunting reduction in develo** countries

MNN Mbuya, JH Humphrey - Maternal & child nutrition, 2016 - Wiley Online Library
In 2011, one in every four (26%) children under 5 years of age worldwide was stunted. The
realization that most stunting cannot be explained by poor diet or by diarrhoea, nor …

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

JL Gehrig, S Venkatesh, HW Chang, MC Hibberd… - Science, 2019 - science.org
INTRODUCTION There is a dimension to postnatal human development that involves
assembly of microbial communities in different body habitats, including the gut. Children with …

Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

M Schwarzer, UK Gautam, K Makki, A Lambert… - Science, 2023 - science.org
The intestinal microbiota is known to influence postnatal growth. We previously found that a
strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic …

Pathogen-specific burdens of community diarrhoea in develo** countries: a multisite birth cohort study (MAL-ED)

JA Platts-Mills, S Babji, L Bodhidatta, J Gratz… - The Lancet Global …, 2015 - thelancet.com
Background Most studies of the causes of diarrhoea in low-income and middle-income
countries have looked at severe disease in people presenting for care, and there are few …

Effect of a community-led sanitation intervention on child diarrhoea and child growth in rural Mali: a cluster-randomised controlled trial

AJ Pickering, H Djebbari, C Lopez… - The Lancet Global …, 2015 - thelancet.com
Background Community-led total sanitation (CLTS) uses participatory approaches to
mobilise communities to build their own toilets and stop open defecation. Our aim was to …

Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study

MN Kosek, T Ahmed, Z Bhutta, L Caulfield… - …, 2017 - thelancet.com
Background Environmental enteropathy (EE), the adverse impact of frequent and numerous
enteric infections on the gut resulting in a state of persistent immune activation and altered …

The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical …

Clinical Infectious Diseases, 2014 - academic.oup.com
Highly prevalent conditions with multiple and complex underlying etiologies are a challenge
to public health. Undernutrition, for example, affects 20% of children in the develo** world …

Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction

A Bein, CW Fadel, B Swenor, W Cao… - Nature Biomedical …, 2022 - nature.com
Environmental enteric dysfunction (EED)—a chronic inflammatory condition of the intestine—
is characterized by villus blunting, compromised intestinal barrier function and reduced …

Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics

LV Blanton, MJ Barratt, MR Charbonneau, T Ahmed… - Science, 2016 - science.org
BACKGROUND Childhood undernutrition is a global health challenge. Undernutrition in
early life is associated with a number of adverse outcomes, including persistent stunting …