Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Several pharmacological, dietary, and genetic interventions that increase mammalian
lifespan are known, but general principles of lifespan extension remain unclear. Here, we …

Rodents have been the primary model for mammalian nutritional physiology for decades.
Despite an extensive body of literature, controversies remain around the effects of specific …

Nutrition profoundly influences the risk for many age‐related diseases. Whether nutrition
influences human aging biology directly is less clear. Studies in different animal species …

Highlights•Nutrition regulates the rates of egg production.•Nutrients impact egg production
rates with differing dynamics.•Egg production rate is a function of rates of egg development.• …

Limited resources affect an organism's physiology through the conserved metabolic
pathway, the mechanistic target of rapamycin (mTOR). Males and females often react …

Premature aging causes morphological and functional changes in the kidney, leading to
chronic kidney disease (CKD). CKD is a global public health issue with far-reaching …

Hydrogen sulfide (H 2 S) is one of the biologically active gases (gasotransmitters), which
plays an important role in various physiological processes and aging. Its production in the …

Resources are needed for growth, reproduction and survival, and organisms must trade off
limited resources among competing processes. Nutritional availability in organisms is …