How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

MB Goodman, P Sengupta - Genetics, 2019‏ - academic.oup.com
Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Temperature sensation: from molecular thermosensors to neural circuits and coding principles

R **ao, XZS Xu - Annual review of physiology, 2021‏ - annualreviews.org
Temperature is a universal cue and regulates many essential processes ranging from
enzymatic reactions to species migration. Due to the profound impact of temperature on …

G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans

K Ohnishi, T Sokabe, T Miura, M Tominaga… - Nature …, 2024‏ - nature.com
Animals must sense and acclimatize to environmental temperatures for survival, yet their
thermosensing mechanisms other than transient receptor potential (TRP) channels remain …

Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging

H Cheng, D Chen, X Li, U Al-Sheikh, D Duan, Y Fan… - Neuron, 2024‏ - cell.com
Phasic (fast) and tonic (sustained) inhibition of γ-aminobutyric acid (GABA) are fundamental
for regulating day-to-day activities, neuronal excitability, and plasticity. However, the …

Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans

CG Martin, JS Bent, T Hill, I Topalidou, A Singhvi - Developmental Cell, 2024‏ - cell.com
For an organ to maintain correct architecture and function, its diverse cellular components
must coordinate their size and shape. Although cell-intrinsic mechanisms driving homotypic …

Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity

N Harris, SG Bates, Z Zhuang, M Bernstein… - Current biology, 2023‏ - cell.com
Neurons modify their transcriptomes in response to an animal's experience. How specific
experiences are transduced to modulate gene expression and precisely tune neuronal …

Integration of plasticity mechanisms within a single sensory neuron of C. elegans actuates a memory

JD Hawk, AC Calvo, P Liu, A Almoril-Porras, A Aljobeh… - Neuron, 2018‏ - cell.com
Neural plasticity, the ability of neurons to change their properties in response to
experiences, underpins the nervous system's capacity to form memories and actuate …

[HTML][HTML] The neural basis of heat seeking in a human-infective parasitic worm

AS Bryant, F Ruiz, JH Lee, EA Hallem - Current Biology, 2022‏ - cell.com
Soil-transmitted parasitic nematodes infect over one billion people and cause devastating
morbidity worldwide. Many of these parasites have infective larvae that locate hosts using …

The extraordinary AFD thermosensor of C. elegans

MB Goodman, P Sengupta - Pflügers Archiv-European Journal of …, 2018‏ - Springer
The nematode C. elegans exhibits complex thermal experience-dependent navigation
behaviors in response to environmental temperature changes of as little as 0.01° C over a> …

Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity

A Takeishi, J Yeon, N Harris, W Yang, P Sengupta - Elife, 2020‏ - elifesciences.org
Internal state alters sensory behaviors to optimize survival strategies. The neuronal
mechanisms underlying hunger-dependent behavioral plasticity are not fully characterized …