Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …

Chronic stress and the accompanying long-term elevation of glucocorticoids (GCs), the
stress hormones of the body, increase the risk and accelerate the progression of Alzheimer's …

Impaired brain glucose metabolism is an early indicator of Alzheimer's disease (AD);
however, the fundamental mechanism is unknown. In this study, we found a substantial …

Alzheimer's disease is a progressive neurological disorder causing memory loss and
cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration …

Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their
activities. The dynamic nature of these sites and their small size hinder analysis by current …

As the global population ages, the incidence of elderly patients with dementia, represented
by Alzheimer's disease (AD), will continue to increase. Previous studies have suggested that …

Prenatal exposure to infections is a risk factor for neurodevelopmental disorders in offspring,
and alterations in mitochondrial function are discussed as a potential underlying factor …

Nitric oxide can covalently modify cysteine thiols on target proteins to alter that protein's
function in a process called S-nitrosylation (SNO). S-nitrosylation of synaptic proteins plays …

The apolipoprotein E4 (APOE4) allele represents the major genetic risk factor for
Alzheimer's disease (AD). In contrast, APOE2 is known to lower the AD risk, while APOE3 is …

Mitochondrial dysfunctions are key features of Alzheimer's disease (AD). The occurrence of
these disturbances in the peripheral cells of AD patients and their potential correlation with …