Activation or exhaustion of CD8+ T cells in patients with COVID-19

MS Rha, EC Shin - Cellular & molecular immunology, 2021 - nature.com
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity

D Lapuente, TH Winkler, M Tenbusch - Cellular & molecular …, 2024 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
prompted scientific, medical, and biotech communities to investigate infection-and vaccine …

The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

C Schultheiß, E Willscher, L Paschold, C Gottschick… - Cell Reports …, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …

[HTML][HTML] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

B Krämer, R Knoll, L Bonaguro, M ToVinh, J Raabe… - Immunity, 2021 - cell.com
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …

Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19

S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …

SARS-CoV-2 mRNA vaccines: immunological mechanism and beyond

E Bettini, M Locci - Vaccines, 2021 - mdpi.com
To successfully protect against pathogen infection, a vaccine must elicit efficient adaptive
immunity, including B and T cell responses. While B cell responses are key, as they can …

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

G Song, W He, S Callaghan, F Anzanello… - Nature …, 2021 - nature.com
Pre-existing immunity to seasonal endemic coronaviruses could have profound
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

MH Cheng, S Zhang, RA Porritt, M Noval Rivas… - Proceedings of the …, 2020 - pnas.org
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a
newly recognized condition in children with recent severe acute respiratory syndrome …

HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children

RA Porritt, L Paschold, MN Rivas, MH Cheng… - The Journal of clinical …, 2021 - jci.org
Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory syndrome
associated with SARS-CoV-2 infection, shares clinical features with toxic shock syndrome …

Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19

X Chen, Z Pan, S Yue, F Yu, J Zhang, Y Yang… - Signal transduction and …, 2020 - nature.com
COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection. It is
currently unknown as to the correlation between the magnitude of neutralizing antibody …