Mutations are the raw material on which evolution acts, and knowledge of their frequency
and genomic distribution is crucial for understanding how evolution operates at both long …

Motivation Bacterial genomes present more variability than human genomes, which requires
important adjustments in computational tools that are developed for human data. In …

Germline mutations are the raw material for natural selection, driving species evolution and
the generation of earth's biodiversity. Without this driver of genetic diversity, life on earth …

There is no effective vaccine against malaria; therefore, chemotherapy is to date the only
choice to fight against this infectious disease. However, there is growing evidences of drug …

While the malaria parasite Plasmodium falciparum has low average genome-wide diversity
levels, likely due to its recent introduction from a gorilla-infecting ancestor (approximately …

The structure of complex networks can be characterized by counting and analysing network
motifs. Motifs are small graph structures that occur repeatedly in a network, such as triangles …

Background Lumefantrine and mefloquine are used worldwide in artemisinin-based
combination therapy (ACT) of malaria. Better understanding of drug susceptibility and …

While the malaria parasite P. falciparum has low average genome-wide diversity levels,
likely due to its recent introduction from a gorilla-infecting ancestor (∼ 10,000-50,000 years …

Studying structural variants (SV) in populations is crucial since they cause more diversity
and have more effects on gene function than small variants. However, population scale …

Genetic factors are important factors in chronic obstructive pulmonary disease (COPD)
onset. Plenty of risk and new causative genes for COPD have been identified in patients of …