Label-free microfluidic cell sorting and detection for rapid blood analysis

N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …

A review of circulating tumour cell enrichment technologies

AJ Rushton, G Nteliopoulos, JA Shaw, RC Coombes - Cancers, 2021 - mdpi.com
Simple Summary Circulating tumour cells (CTCs) are cancer cells shed into the bloodstream
from tumours and their analysis can provide important insights into cancer detection and …

Technologies for circulating tumor cell separation from whole blood

P Bankó, SY Lee, V Nagygyörgy, M Zrínyi… - Journal of hematology & …, 2019 - Springer
The importance of early cancer diagnosis and improved cancer therapy has been clear for
years and has initiated worldwide research towards new possibilities in the care strategy of …

Exodisc for rapid, size-selective, and efficient isolation and analysis of nanoscale extracellular vesicles from biological samples

HK Woo, V Sunkara, J Park, TH Kim, JR Han, CJ Kim… - ACS …, 2017 - ACS Publications
Extracellular vesicles (EVs) are cell-derived, nanoscale vesicles that carry nucleic acids and
proteins from their cells of origin and show great potential as biomarkers for many diseases …

Circulating tumor cell isolation, culture, and downstream molecular analysis

S Sharma, R Zhuang, M Long, M Pavlovic, Y Kang… - Biotechnology …, 2018 - Elsevier
Circulating tumor cells (CTCs) are a major contributor of cancer metastases and hold a
promising prognostic significance in cancer detection. Performing functional and molecular …

Size-based separation methods of circulating tumor cells

SJ Hao, Y Wan, YQ **a, X Zou, SY Zheng - Advanced drug delivery reviews, 2018 - Elsevier
Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the
peripheral bloodstream. Compared to other “liquid biopsy” portfolios such as exosome …

Centrifugal microfluidics for biomedical applications

R Gorkin, J Park, J Siegrist, M Amasia, BS Lee… - Lab on a Chip, 2010 - pubs.rsc.org
The centrifugal microfluidic platform has been a focus of academic and industrial research
efforts for almost 40 years. Primarily targeting biomedical applications, a range of assays …

Cascaded microfluidic circuits for pulsatile filtration of extracellular vesicles from whole blood for early cancer diagnosis

Z Li, C Liu, Y Cheng, Y Li, J Deng, L Bai, L Qin… - Science …, 2023 - science.org
Tumor-derived extracellular vesicles (EVs) hold the potential to substantially improve
noninvasive early diagnosis of cancer. However, analysis of nanosized EVs in blood …

A fidget spinner for the point-of-care diagnosis of urinary tract infection

I Michael, D Kim, O Gulenko, S Kumar… - Nature biomedical …, 2020 - nature.com
The point-of-care detection of pathogens in biological samples in resource-limited settings
should be inexpensive, rapid, portable, simple and accurate. Here, we describe a custom …

Microfluidic technologies for circulating tumor cell isolation

H Cho, J Kim, H Song, KY Sohn, MH Jeon, KH Han - Analyst, 2018 - pubs.rsc.org
Metastasis is the main cause of tumor-related death, and the dispersal of tumor cells through
the circulatory system is a critical step in the metastatic process. Early detection and analysis …