Solid-state nanopores are nm sized apertures formed in thin synthetic membranes. These
single molecule sensors have been used in a variety of biophysical and diagnostic …

Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

Small RNA molecules have an important role in gene regulation and RNA silencing therapy,
but it is challenging to detect these molecules without the use of time-consuming radioactive …

Sensitivity and specificity are two most important factors to take into account for molecule
sensing, chemical detection and disease diagnosis. A perfect sensitivity is to reach the level …

Single-molecule counting is the most accurate and precise method for determining the
concentration of a biomarker in solution and is leading to the emergence of digital diagnostic …

MicroRNAs are short RNA molecules that regulate gene expression, and have been
investigated as potential biomarkers because their expression levels are correlated with …

Provided herein are methods and devices for characterizing a biomolecule parameter by a
nanopore-containing mem brane, and also methods for making devices that can be used in …

DNA sequencing is in the throes of an enormous technolog-ical shift marked by dramatic
throughput increases, a precipitously drop** per-base cost of raw sequence, and an …

Solid-state nanopores are now well established as single-biomolecule sensors that hold
great promise as sensing elements in diagnostic and sequencing applications. However …

The solid‐state nanopore has attracted much attention as a next‐generation DNA
sequencing tool or a single‐molecule biosensor platform with its high sensitivity of …