The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Skeletal muscle health is dependent on the optimal function of its mitochondria. With
advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part …

Despite the recent progress in the broad‐scaled analysis of proteins in body fluids, there is
still a lack in protein profiling approaches for biomarkers of rare diseases. Scarcity of …

Skeletal muscle is a large organ that accounts for up to half the total mass of the human
body. A progressive decline in muscle mass and strength occurs with ageing and in some …

Sarcopenia, the age-related loss of skeletal muscle mass and function, is becoming more
prevalent as the lifespan continues to increase in most populations. As sarcopenia is highly …

Key points Muscle weakness in old age is due in large part to an overall loss of skeletal
muscle tissue, but it remains uncertain how much also stems from alterations in the …

To gain a deeper understanding of skeletal muscle function in younger age and aging in
elderly, identification of molecular signatures regulating these functions under physiological …

Resistance exercise training (RET) can counteract negative features of muscle ageing but
older age associates with reduced adaptive capacity to RET. Altered muscle protein …