lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions

EM McCabe, TP Rasmussen - Seminars in cancer biology, 2021 - Elsevier
Epithelial to mesenchymal transition (EMT) is a cellular process in which cells composing
epithelial tissue lose requirements for physical contact with neighboring cells and acquire …

[HTML][HTML] Pharmacological basis and new insights of taxifolin: A comprehensive review

A Das, R Baidya, T Chakraborty, AK Samanta… - Biomedicine & …, 2021 - Elsevier
The pharmacological characteristics of phytochemicals have prompted a lot of interest in
their application in disease management. Due to the high incidence of cancer related …

[HTML][HTML] Integrated genomic and molecular characterization of cervical cancer

Cancer Genome Atlas Research Network - Nature, 2017 - ncbi.nlm.nih.gov
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide.
Reported here is an extensive molecular characterization of 228 primary cervical cancers …

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

AM Krebs, J Mitschke, M Lasierra Losada… - Nature cell …, 2017 - nature.com
Metastasis is the major cause of cancer-associated death. Partial activation of the epithelial-
to-mesenchymal transition program (partial EMT) was considered a major driver of tumour …

The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?

S Brabletz, T Brabletz - EMBO reports, 2010 - embopress.org
Epithelial‐to‐mesenchymal transition (EMT) is a fundamental process in development and
disease. Zinc‐finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are …

TGF-β-induced endothelial-mesenchymal transition in fibrotic diseases

E Pardali, G Sanchez-Duffhues… - International journal of …, 2017 - mdpi.com
Fibrotic diseases are characterized by net accumulation of extracellular matrix proteins in
affected organs leading to their dysfunction and ultimate failure. Myofibroblasts have been …

To differentiate or not—routes towards metastasis

T Brabletz - Nature Reviews Cancer, 2012 - nature.com
Why are many metastases differentiated? Invading and disseminating carcinoma cells can
undergo an epithelial–mesenchymal transition (EMT), which is associated with a gain of …

Cancer invasion: patterns and mechanisms

NV Krakhmal, MV Zavyalova, EV Denisov… - Acta Naturae …, 2015 - cyberleninka.ru
Cancer invasion and the ability of malignant tumor cells for directed migration and
metastasis have remained a focus of research for many years. Numerous studies have …

Analysis of the role of the Hippo pathway in cancer

Y Han - Journal of translational medicine, 2019 - Springer
Cancer is a serious health issue in the world due to a large body of cancer-related human
deaths, and there is no current treatment available to efficiently treat the disease as the …

[HTML][HTML] The role of miRNAs in colorectal cancer progression and chemoradiotherapy

N Zhang, X Hu, Y Du, J Du - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth
most deadly cancer worldwide. CRC accounts for approximately 10% of all new cancer …