Precision medicine in human heart modeling: perspectives, challenges, and opportunities

M Peirlinck, FS Costabal, J Yao, JM Guccione… - … and modeling in …, 2021 - Springer
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

[HTML][HTML] Computational fluid dynamics modelling in cardiovascular medicine

PD Morris, A Narracott, H von Tengg-Kobligk… - Heart, 2016 - heart.bmj.com
This paper reviews the methods, benefits and challenges associated with the adoption and
translation of computational fluid dynamics (CFD) modelling within cardiovascular medicine …

Patient-specific cardiovascular computational modeling: diversity of personalization and challenges

RA Gray, P Pathmanathan - Journal of cardiovascular translational …, 2018 - Springer
Patient-specific computer models have been developed representing a variety of aspects of
the cardiovascular system spanning the disciplines of electrophysiology, electromechanics …

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

M Fedele, A Quarteroni - International Journal for Numerical …, 2021 - Wiley Online Library
In order to simulate the cardiac function for a patient‐specific geometry, the generation of the
computational mesh is crucially important. In practice, the input is typically a set of …

Image-based large-eddy simulation in a realistic left heart

C Chnafa, S Mendez, F Nicoud - Computers & Fluids, 2014 - Elsevier
A numerical framework allowing insight in fluid dynamics inside patient-specific human
hearts is presented. The heart cavities and their wall dynamics are extracted from medical …

Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia

A Lopez-Perez, R Sebastian, M Izquierdo… - Frontiers in …, 2019 - frontiersin.org
In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …

Digital twin for drug discovery and development—the virtual liver

K Subramanian - Journal of the Indian Institute of Science, 2020 - Springer
Digital twins are defined as digital replicas of processes, systems or devices developed to
foster deeper understanding and prediction. While the concept of digital twins has largely …

Computational modeling of the human atrial anatomy and electrophysiology

O Dössel, MW Krueger, FM Weber, M Wilhelms… - Medical & biological …, 2012 - Springer
This review article gives a comprehensive survey of the progress made in computational
modeling of the human atria during the last 10 years. Modeling the anatomy has emerged …

Patient-specific computer simulation to elucidate the role of contact pressure in the development of new conduction abnormalities after catheter-based implantation of …

G Rocatello, N El Faquir, G De Santis… - Circulation …, 2018 - Am Heart Assoc
Background—The extent to which pressure generated by the valve on the aortic root plays a
role in the genesis of conduction abnormalities after transcatheter aortic valve replacement …

[HTML][HTML] A computationally efficient physiologically comprehensive 3D–0D closed-loop model of the heart and circulation

CM Augustin, MAF Gsell, E Karabelas… - Computer methods in …, 2021 - Elsevier
Computer models of cardiac electro-mechanics (EM) show promise as an effective means
for the quantitative analysis of clinical data and, potentially, for predicting therapeutic …