A molecular clock in the suprachiasmatic nucleus of the anterior hypothalamus, which is
entrained by the dark-light cycle and controls the sleep-wake cycle, regulates circadian …

The circadian clock system drives daily rhythms in physiology, metabolism, and behavior in
mammals. Molecular mechanisms of this system consist of multiple clock genes, with …

Parkinson's disease (PD) is the second most common neurodegenerative disease, which
manifests with both motor and non-motor symptoms. Circadian rhythm dysregulation, as one …

Schizophrenia (SZ) and autism spectrum disorders (ASD) are characterised by marked
language deficits, but it is not clear how these arise from gene mutations associated with the …

Schizophrenia is characterized by marked language deficits, but it is not clear how these
deficits arise from the alteration of genes related to the disease. The goal of this paper is to …

NPAS2, a circadian rhythm gene encoding the neuronal PAS domain protein 2 (NPAS2),
has received widespread attention because of its complex functions in cells and diverse …

Type 1 diabetes mellitus (T1DM) is a metabolic disorder for which the underlying molecular
mechanisms remain largely unclear. This investigation aimed to elucidate essential …

The field of circadian research on Restless Legs Syndrome (RLS) and periodic limb
movements (PLMs) is reviewed in general. RLS has five obligatory criteria for diagnosis:(1) …

There are strong epidemiologic ties between restless legs syndrome (RLS) and a wide array
of psychiatric conditions. Although the mechanism of this association is not fully understood …

Recent experimental animal studies suggested that the circadian locomotor output cycles
kaput protein gene (CLOCK) has been reported to play a critical role in sperm function and …