Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Inorganic polyphosphates (polyP) consist of linear chains of orthophosphate residues,
linked by high-energy phosphoanhydride bonds. They are evolutionarily old biopolymers …

Covering: up to June 2006 The indolocarbazole family of natural products, including the
biosynthetically related bisindolylmaleimides, is reviewed (with 316 references cited). The …

A wide variety of protein post‐translational modifications (PTM s) decorate cellular proteins,
regulating their structure, interactions and ultimately their function. The density of co …

Mitogen-activated protein (MAP) kinases belong to a highly conserved family of Ser-Thr
protein kinases in the human kinome and have diverse roles in broad physiological …

Mitogen-activated protein kinases (MAPKs) have a docking groove that interacts with linear
“docking” motifs in binding partners. To determine the structural basis of binding specificity …

Mass spectrometry-based phosphoproteomics is becoming an essential methodology for the
study of global cellular signaling. Numerous bioinformatics resources are available to …

Background: Calculation of ligand-binding affinity is an open problem in computational
medicinal chemistry. The ability to computationally predict affinities has a beneficial impact …

Mutations in kinases are abundant and critical to study signaling pathways and regulatory
roles in human disease, especially in cancer. Somatic mutations in kinase genes can affect …