Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular
disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in …

Simple Summary Drug resistance is the “Achilles' heel” in current oncology. In this sense,
the clinical management of HER2 breast carcinomas (tumors with overexpression …

Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs,
contributing to resistance to therapies. This includes a higher demand for cholesterol, which …

With resistance to most antimalarials increasing, it is imperative that new drugs are
developed. We previously identified an aryl acetamide compound, MMV006833 (M-833) …

A large proportion of the heritability of pancreatic cancer risk remains elusive, and the
contribution of specific mRNA splicing events to pancreatic cancer susceptibility has not …

The global prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease
(MASLD) is increasing, now affecting 25%–30% of the population worldwide. MASLD …

Abstract Aims Steroidogenic acute regulatory (StAR)-related lipid transfer domain-3
(STARD3) is a sterol-binding protein that facilitates cholesterol transport between cellular …

HER2-positive gastric cancer is a distinct tumor subtype, accounting for~ 10% of gastric
cancer cases. It is characterized by HER2 overexpression and responds well to HER2 …

Lipid composition is conserved within sub-cellular compartments to maintain cell function.
Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria …

Lutein, zeaxanthin, and mesozeaxanthin, collectively termed as macular pigments, are key
carotenoids integral to optimized central vision of the eye. Therefore, nutraceuticals and …