Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Permanent epigenetic silencing using programmable editors equipped with transcriptional
repressors holds great promise for the treatment of human diseases,–. However, to unlock …

RNAs localizing to the outer cell surface have been recently identified in mammalian cells,
including RNAs with glycan modifications known as glycoRNAs. However, the functional …

The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of
tools for probing their emergence at high resolution. Here we present macsGESTALT, an …

Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic
functions. However, how mitochondria sense the abundance of metabolites and regulate …

Background Development of efficient strategies has always been one of the great
perspectives for biotechnologists. During the last decade, genome editing of different …

Plant pathogens pose a major threat to crop productivity. Typically, phytopathogens exploit
plants' susceptibility (S) genes to facilitate their proliferation. Disrupting these S genes may …

Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies.
Emerging evidence suggests that certain epigenetic and transcriptional regulators drive …

To improve food security, plant biology research aims to improve crop yield and tolerance to
biotic and abiotic stress, as well as increasing the nutrient contents of food. Conventional …