Therapeutic targeting of α7 nicotinic acetylcholine receptors
RL Papke, NA Horenstein, H Khoshbouei - Pharmacological Reviews, 2021 - Elsevier
The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …
[HTML][HTML] Small molecule ligands for α9* and α7 nicotinic receptors: A survey and an update, respectively
Abstract The α9-and α7-containing nicotinic acetylcholine receptors (nAChRs) mediate
numerous physiological and pathological processes by complex mechanisms that are …
numerous physiological and pathological processes by complex mechanisms that are …
[HTML][HTML] An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors
O Alijevic, D McHugh, L Rufener, A Mazurov, J Hoeng… - Phytochemistry, 2020 - Elsevier
Nicotinic acetylcholine receptor (nAChR) subtype-selective pharmacological profiles of
tobacco alkaloids are essential for understanding the physiological effects of tobacco …
tobacco alkaloids are essential for understanding the physiological effects of tobacco …
Blockade of α7 nicotinic acetylcholine receptors inhibit nicotine-induced tumor growth and vimentin expression in non-small cell lung cancer through MEK/ERK …
Nicotine can stimulate the progression of non-small cell lung cancer (NSCLC) through
nicotinic acetylcholine receptors (nAChRs). The persistent proliferation of cancer cells is one …
nicotinic acetylcholine receptors (nAChRs). The persistent proliferation of cancer cells is one …
Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists
Y Xue, J Tang, X Ma, Q Li, B **e, Y Hao, H **… - European Journal of …, 2016 - Elsevier
Human α7 nicotinic acetylcholine receptor (nAChR) is a promising therapeutic target for the
treatment of schizophrenia accompanied with cognitive impairment. Herein, we report the …
treatment of schizophrenia accompanied with cognitive impairment. Herein, we report the …
Synthesis and biological evaluation of novel triazine derivatives as positive allosteric modulators of α7 nicotinic acetylcholine receptors
X Wang, H **ao, J Wang, Z Huang… - Journal of Medicinal …, 2021 - ACS Publications
Enhancing neuronal α7 nicotinic acetylcholine receptor (α7 nAChR) function can alleviate
cognitive deficits. Here, we report the design, synthesis, and evaluation of N-(4 …
cognitive deficits. Here, we report the design, synthesis, and evaluation of N-(4 …
Design and synthesis of novel positive allosteric modulators of α7 nicotinic acetylcholine receptors with the ability to rescue auditory gating deficit in mice
Y Li, L Sun, T Yang, W Jiao, J Tang… - Journal of Medicinal …, 2018 - ACS Publications
A series of novel thiazolo [4, 5-d] pyrimidin-7 (6 H)-ones (3aa–3eq) were designed,
synthesized, and evaluated as the type I positive allosteric modulators of human α7 nAChR …
synthesized, and evaluated as the type I positive allosteric modulators of human α7 nAChR …
Downregulation of HOTAIR reduces neuronal pyroptosis by targeting miR-455-3p/NLRP1 axis in propofol-treated neurons in vitro
H Gong, X Wan, Y Zhang, S Liang - Neurochemical Research, 2021 - Springer
Propofol is one of the most common intravenous anesthetics which may cause neuronal cell
death in young mice. HOX transcript antisense RNA (HOTAIR) was abnormally expressed in …
death in young mice. HOX transcript antisense RNA (HOTAIR) was abnormally expressed in …
Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse …
L Sun, T Yang, N Wei, W Lu, W Jiao, Q Zhou… - Acta Pharmacologica …, 2019 - nature.com
The α7 nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated Ca2+-permeable
homopentameric ion channel implicated in cognition and neuropsychiatric disorders …
homopentameric ion channel implicated in cognition and neuropsychiatric disorders …
Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation
Y Xue, X He, T Yang, Y Wang, Z Liu, G Zhang… - European Journal of …, 2019 - Elsevier
The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a promising therapeutic
target for schizophrenia. In our previous work, a novel series of α7-nAChR agonists bearing …
target for schizophrenia. In our previous work, a novel series of α7-nAChR agonists bearing …