Water in nanopores and biological channels: a molecular simulation perspective
This Review explores the dynamic behavior of water within nanopores and biological
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …
The nicotinic acetylcholine receptor and its pentameric homologs: toward an allosteric mechanism of signal transduction at the atomic level
M Cecchini, PJ Corringer… - Annual Review of …, 2024 - annualreviews.org
The nicotinic acetylcholine receptor has served, since its biochemical identification in the
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
De novo formation of the double-membrane compartment autophagosome is seeded by
small vesicles carrying membrane protein autophagy-related 9 (ATG9), the function of which …
small vesicles carrying membrane protein autophagy-related 9 (ATG9), the function of which …
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor
The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …
Molecular architecture of the human caveolin-1 complex
Membrane-sculpting proteins shape the morphology of cell membranes and facilitate
remodeling in response to physiological and environmental cues. Complexes of the …
remodeling in response to physiological and environmental cues. Complexes of the …
Architecture and self-assembly of the jumbo bacteriophage nuclear shell
Bacteria encode myriad defences that target the genomes of infecting bacteriophage,
including restriction–modification and CRISPR–Cas systems. In response, one family of …
including restriction–modification and CRISPR–Cas systems. In response, one family of …
Constructing ion channels from water-soluble α-helical barrels
The design of peptides that assemble in membranes to form functional ion channels is
challenging. Specifically, hydrophobic interactions must be designed between the peptides …
challenging. Specifically, hydrophobic interactions must be designed between the peptides …
Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor
Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between …
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between …
Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor
Fast synaptic communication requires receptors that respond to the presence of
neurotransmitter by opening an ion channel across the post-synaptic membrane. The …
neurotransmitter by opening an ion channel across the post-synaptic membrane. The …
[HTML][HTML] Structural mechanisms of GABAA receptor autoimmune encephalitis
Autoantibodies targeting neuronal membrane proteins can cause encephalitis, seizures,
and severe behavioral abnormalities. While antibodies for several neuronal targets have …
and severe behavioral abnormalities. While antibodies for several neuronal targets have …