Exercise is considered an important component of effective chronic pain management and it
is well-established that long-term exercise training provides pain relief. In healthy, pain-free …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

Neuromuscular system enabled muscle functions are critical for body movements, such as
rhythmic motions and other complexed movements. Imparting artificial neuromuscular …

Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Objective Radiographic measures of the pathologic changes of knee osteoarthritis (OA)
have shown modest associations with clinical pain. We sought to evaluate possible …

Hyperexcitability of the central nervous system (CNS) has been suggested to play an
important role in the chronic pain experienced by osteoarthritis (OA) patients. A systematic …

Studies have suggested that quantitative sensory testing (QST) might hold a predictive value
for the development of chronic postoperative pain and the response to pharmacological …

Objective The modest association between radiographic joint damage and pain in
osteoarthritis (OA) has led to the suggestion of facilitated central pain processing. This study …

Chronic pain, a frequently neglected problem, is treated with different classes of drugs.
Current agents are limited by incomplete efficacy and dose-limiting side-effects. Knowledge …