The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology
The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …
[HTML][HTML] Mitochondrial channels: ion fluxes and more
I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …
molecular identification of some of the channels. An integrative approach using genetics …
[HTML][HTML] Ion channels in the regulation of apoptosis
A Kondratskyi, K Kondratska, R Skryma… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism
utilized by multicellular organisms for disposal of cells that are no longer needed or …
utilized by multicellular organisms for disposal of cells that are no longer needed or …
Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo
The potassium channel Kv1. 3 is highly expressed in the mitochondria of various cancerous
cells. Here we show that direct inhibition of Kv1. 3 using two mitochondria-targeted inhibitors …
cells. Here we show that direct inhibition of Kv1. 3 using two mitochondria-targeted inhibitors …
Voltage-gated potassium channel Kv1. 3 as a target in therapy of cancer
A Teisseyre, A Palko-Labuz, K Sroda-Pomianek… - Frontiers in …, 2019 - frontiersin.org
Voltage-gated potassium channel Kv1. 3 is an integral membrane protein, which is
selectively permeable for potassium ions and is activated upon a change of membrane …
selectively permeable for potassium ions and is activated upon a change of membrane …
[HTML][HTML] Involvement of potassium channels in the progression of cancer to a more malignant phenotype
N Comes, A Serrano-Albarras, J Capera… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Potassium channels are a diverse group of pore-forming transmembrane proteins that
selectively facilitate potassium flow through an electrochemical gradient. They participate in …
selectively facilitate potassium flow through an electrochemical gradient. They participate in …
Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase
A Manago, KA Becker, A Carpinteiro… - Antioxidants & redox …, 2015 - liebertpub.com
Abstract Aims: Pulmonary infections with Pseudomonas aeruginosa are a serious clinical
problem and are often lethal. Because many strains of P. aeruginosa are resistant to …
problem and are often lethal. Because many strains of P. aeruginosa are resistant to …
Mitochondrial potassium channels as druggable targets
Mitochondrial potassium channels have been described as important factors in cell pro-life
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …
Mitochondrial K+ channels and their implications for disease mechanisms
The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …
Targeting ion channels for cancer treatment: current progress and future challenges
AL Capatina, D Lagos, WJ Brackenbury - Targets of Cancer Diagnosis and …, 2020 - Springer
Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …
of processes such as maintenance of cellular osmolarity and membrane potential, motility …