Immunotherapy for glioblastoma: the promise of combination strategies
Glioblastoma (GBM) treatment has remained almost unchanged for more than 20 years. The
current standard of care involves surgical resection (if possible) followed by concomitant …
current standard of care involves surgical resection (if possible) followed by concomitant …
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors
L Zhang, Y Liu, H Huang, H **e, B Zhang, W **a… - Advanced drug delivery …, 2022 - Elsevier
Malignant brain tumors, a heterogeneous group of primary and metastatic neoplasms in the
central nervous system (CNS), are notorious for their highly invasive and devastating …
central nervous system (CNS), are notorious for their highly invasive and devastating …
Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier
Microbubble-enhanced ultrasound provides a noninvasive physical method to locally
overcome major obstacles to the accumulation of blood-borne therapeutics in the brain …
overcome major obstacles to the accumulation of blood-borne therapeutics in the brain …
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
Applications of focused ultrasound for the treatment of glioblastoma: a new frontier
Simple Summary Glioblastoma (GBM) is a common primary brain tumor with a short median
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …
Focused ultrasound for the treatment of glioblastoma
JW Roberts, L Powlovich, N Sheybani… - Journal of Neuro …, 2022 - Springer
Purpose Six years ago, in 2015, the Focused Ultrasound Foundation sponsored a workshop
to discuss, and subsequently transition the landscape, of focused ultrasound as a new …
to discuss, and subsequently transition the landscape, of focused ultrasound as a new …
Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade
Despite the challenges in treating glioblastomas (GBMs) with immune adjuvants, increasing
evidence suggests that targeting the immune cells within the tumor microenvironment (TME) …
evidence suggests that targeting the immune cells within the tumor microenvironment (TME) …
Translation of focused ultrasound for blood-brain barrier opening in glioma
Survival outcomes for patients with glioblastoma multiforme (GBM) have remained poor for
the past 15 years, reflecting a clear challenge in the development of more effective treatment …
the past 15 years, reflecting a clear challenge in the development of more effective treatment …
ImmunoPET: antibody-based PET imaging in solid tumors
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …
combining the high sensitivity of PET with the specific targeting ability of monoclonal …