Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque
endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction …

Clonal expansion refers to the proliferation and selection of advantageous “clones” that are
better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced …

BACKGROUND: Studies in humans and mice using the expression of an X-linked gene or
lineage tracing, respectively, have suggested that clones of smooth muscle cells (SMCs) …

Cardiovascular and cardiometabolic diseases are leading causes of morbidity and mortality
worldwide, driven in part by chronic inflammation. Emerging research suggests that the …

Dysregulated inflammation‐resolution programs are associated with atherosclerosis
progression. Resolvins, in part, mediate inflammation‐resolution programs. Indeed …

Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. While
many cell types contribute to the growing atherosclerotic plaque, the vascular smooth …

BACKGROUND: Atherosclerosis, a leading cause of cardiovascular disease, involves the
pathological activation of various cell types, including immunocytes (eg, macrophages and T …

Vascular smooth muscle cells, endothelial cells and macrophages undergo phenotypic
conversions throughout atherosclerosis progression, both as a consequence of chronic …

Hematopoietic stem cells (HSCs) generate all blood cell lineages responsible for tissue
oxygenation, life-long hematopoietic homeostasis and immune protection. In adulthood …