Cystic fibrosis, a multi-organ genetic disease, is characterized by abnormal function of the
cystic fibrosis transmembrane conductance regulator (CFTR) protein, a chloride channel at …

Colorectal cancer (CRC) is the third most common cancer in men (746000 cases per year)
and the second most common cancer in women globally (614000 cases per year). The …

The spectrum of disorders involving CFTR (cystic fibrosis transmembrane conductance
regulator) dysfunction correlates with a continuous gradient of CFTR function defined by the …

Background: The cystic fibrosis (CF) sweat gland is defective in β-adrenergically-stimulated
sweat secretion in the coil and chloride reabsorption in the duct. Whereas chloride …

An Italian, 46-year-old female patient carrying the complex allele p.[R74W; V201M; D1270N]
in trans with CFTR dele22_24 was diagnosed at the Cystic Fibrosis (CF) Center of Verona …

CFTR is an anion channel that causes cystic fibrosis (CF) when its activity, equal to channel
number x open probability x conductance (n· PO· γ) is absent or nearly so. CFTR modulators …

The biological diagnosis of cystic fibrosis (CF) is based on a sweat chloride (Cl−)
concentration (SCC)≥ 60 mmol· L− 1 and/or the identification of two allelic CF-causing …

Mutation targeted therapy in cystic fibrosis (CF) is still not eligible for all CF subjects,
especially for cases carrying rare variants such as the CFTR genotype W57G/A234D (c …

Background There is a need to prognosticate the severity of cystic fibrosis (CF) detected by
newborn screening (NBS) by early assessment of CF transmembrane conductance …

Cystic fibrosis research and case reports were robust in the year 2018. This report
summarizes research and cases related to Cystic Fibrosis Transmembrane Conductance …