HMGB1 in health and disease
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
HMGB1 in cancer: good, bad, or both?
Forty years ago, high mobility group box 1 (HMGB1) was discovered in calf thymus and
named according to its electrophoretic mobility in polyacrylamide gels. Now, we know that …
named according to its electrophoretic mobility in polyacrylamide gels. Now, we know that …
γH2AX and cancer
WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
HMGB proteins: interactions with DNA and chromatin
M Štros - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2010 - Elsevier
HMGB proteins are members of the High Mobility Group (HMG) superfamily, possessing a
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …
High-mobility group box 1 and cancer
High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and
extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily …
extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily …
Production of therapeutic proteins in algae, analysis of expression of seven human proteins in the chloroplast of Chlamydomonas reinhardtii
Recombinant proteins are widely used today in many industries, including the
biopharmaceutical industry, and can be expressed in bacteria, yeasts, mammalian and …
biopharmaceutical industry, and can be expressed in bacteria, yeasts, mammalian and …
Histone γH2AX and poly (ADP-ribose) as clinical pharmacodynamic biomarkers
Tumor cells are often deficient in DNA damage response (DDR) pathways, and anticancer
therapies are commonly based on genotoxic treatments using radiation and/or drugs that …
therapies are commonly based on genotoxic treatments using radiation and/or drugs that …
HMGB1 and repair: focus on the heart
L Pellegrini, E Foglio, E Pontemezzo, A Germani… - Pharmacology & …, 2019 - Elsevier
High-mobility group box 1 (HMGB1) is one of the most abundant proteins in eukaryotes and
the best characterized damage-associated molecular pattern (DAMP). The biological …
the best characterized damage-associated molecular pattern (DAMP). The biological …
HMGB1: the jack‐of‐all‐trades protein is a master DNA repair mechanic
SS Lange, KM Vasquez - … in cooperation with the University of …, 2009 - Wiley Online Library
The high mobility group protein B1 (HMGB1) is a highly abundant protein with roles in
several cellular processes, including chromatin structure and transcriptional regulation, as …
several cellular processes, including chromatin structure and transcriptional regulation, as …
HMGB1: roles in base excision repair and related function
Y Liu, R Prasad, SH Wilson - Biochimica et Biophysica Acta (BBA)-Gene …, 2010 - Elsevier
High mobility group box 1 (HMGB1) is a nonhistone architectural protein that is involved in
many biological processes including chromatin remodeling, transcription, cell signaling of …
many biological processes including chromatin remodeling, transcription, cell signaling of …