Assembly and activation of replicative helicases at origin DNA for replication initiation
Q Zhang, WH Lam, Y Zhai - Current Opinion in Structural Biology, 2024 - Elsevier
To initiate DNA replication, it is essential to properly assemble a pair of replicative helicases
at each replication origin. While the general principle of this process applies universally from …
at each replication origin. While the general principle of this process applies universally from …
Embracing Heterogeneity: Challenging the Paradigm of Replisomes as Deterministic Machines
The paradigm of cellular systems as deterministic machines has long guided our
understanding of biology. Advancements in technology and methodology, however, have …
understanding of biology. Advancements in technology and methodology, however, have …
A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome
O Olson, S Pelliciari, ED Heron, TD Deegan - The EMBO journal, 2024 - embopress.org
The eukaryotic replisome is assembled around the CMG (CDC45-MCM-GINS) replicative
helicase, which encircles the leading-strand DNA template at replication forks. When CMG …
helicase, which encircles the leading-strand DNA template at replication forks. When CMG …
RECQL4 is not critical for firing of human DNA replication origins
L Padayachy, SG Ntallis, TD Halazonetis - Scientific Reports, 2024 - nature.com
Human RECQL4, a member of the RecQ helicase family, plays a role in maintaining
genomic stability, but its precise function remains unclear. The N-terminus of RECQL4 has …
genomic stability, but its precise function remains unclear. The N-terminus of RECQL4 has …
FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair
FANCM is a multifunctional DNA repair enzyme that acts as a sensor and coordinator of
replication stress responses, especially interstrand crosslink (ICL) repair mediated by the …
replication stress responses, especially interstrand crosslink (ICL) repair mediated by the …
TopBP1 utilises a bipartite GINS binding mode to support genome replication
Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for
replication origin firing, and as such for faithful genetic inheritance. Our biochemical and …
replication origin firing, and as such for faithful genetic inheritance. Our biochemical and …
Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
AK Yadav, H Polasek-Sedlackova - Communications Biology, 2024 - nature.com
Accurate and complete replication of genetic information is a fundamental process of every
cell division. The replication licensing is the first essential step that lays the foundation for …
cell division. The replication licensing is the first essential step that lays the foundation for …
Unwinding of a eukaryotic origin of replication visualized by cryo-EM
To prevent detrimental chromosome re-replication, DNA loading of a double hexamer of the
minichromosome maintenance (MCM) replicative helicase is temporally separated from …
minichromosome maintenance (MCM) replicative helicase is temporally separated from …
[HTML][HTML] Exploring Aerobic Energy metabolism in breast Cancer: a Mutational Profile of Glycolysis and oxidative phosphorylation
Energy metabolism is a fundamental aspect of the aggressiveness and invasiveness of
breast cancer (BC), the neoplasm that most affects women worldwide. Nonetheless, the …
breast cancer (BC), the neoplasm that most affects women worldwide. Nonetheless, the …
Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa
Metazoan genomes are copied bidirectionally from thousands of replication origins.
Replication initiation entails the assembly and activation of two CMG helicases (Cdc45⋅ …
Replication initiation entails the assembly and activation of two CMG helicases (Cdc45⋅ …