[HTML][HTML] Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences

P Gabarre, C Loens, Y Tamzali, B Barrou… - American Journal of …, 2022 - Elsevier
Our understanding of the involvement of the gut microbiota (GM) in human health has
expanded exponentially over the last few decades, particularly in the fields of metabolism …

Characterizing the gut microbiota in patients with chronic kidney disease

X Hu, S Ouyang, Y **e, Z Gong, J Du - Postgraduate medicine, 2020 - Taylor & Francis
Objectives: Emerging evidence suggests that gut microbiota dysbiosis plays a critical role in
chronic kidney disease (CKD). However, the relationship between altered gut microbiome …

Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity

MR Taylor, KL Flannigan, H Rahim, A Mohamud… - Science …, 2019 - science.org
Mycophenolate mofetil (MMF) is commonly prescribed and has proven advantages over
other immunosuppressive drugs. However, frequent gastrointestinal side effects through an …

The role of the microbiota in Graves' disease and Graves' orbitopathy

J Hou, Y Tang, Y Chen, D Chen - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Graves 'disease (GD) is a clinical syndrome with an enlarged and overactive thyroid gland,
an accelerated heart rate, Graves' orbitopathy (GO), and pretibial myxedema (PTM). GO is …

Human gut bacterial β-glucuronidase inhibition: An emerging approach to manage medication therapy

P Wang, Y Jia, R Wu, Z Chen, R Yan - Biochemical Pharmacology, 2021 - Elsevier
Bacterial β-glucuronidase enzymes (BGUSs) are at the interface of host-microbial metabolic
symbiosis, playing an important role in health and disease as well as medication outcomes …

Fecal microbiota characteristics of Chinese patients with primary IgA nephropathy: a cross-sectional study

X Hu, J Du, Y **e, Q Huang, Y **ao, J Chen, S Yan… - BMC nephrology, 2020 - Springer
Background Growing evidence has shown that the gut-renal connection and gut microbiota
dysbiosis play a critical role in immunoglobulin A nephropathy (IgAN). However, the fecal …

Antibiotic alleviates radiation-induced intestinal injury by remodeling microbiota, reducing inflammation, and inhibiting fibrosis

Z Zhao, W Cheng, W Qu, G Shao, S Liu - ACS omega, 2020 - ACS Publications
Radiation-induced intestinal injury is a common complication of abdominal radiation
therapy. However, the pathological features of radiation-induced intestinal injury and its …

Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

JB Simpson, JJ Sekela, AL Graboski, VB Borlandelli… - Gut …, 2022 - Taylor & Francis
Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to
prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however …