The immunomodulatory mechanism of dexmedetomidine
K Yuki - International immunopharmacology, 2021 - Elsevier
Dexmedetomidine has been increasingly introduced into the perioperative care of surgical
patients. Because a subset of anesthetics/sedatives are immunomodulatory, it is critical to …
patients. Because a subset of anesthetics/sedatives are immunomodulatory, it is critical to …
General anesthesia bullies the gut: a toxic relationship with dysbiosis and cognitive dysfunction
L Liu, L Shang, D **, X Wu, B Long - Psychopharmacology, 2022 - Springer
Perioperative neurocognitive disorder (PND) is a common surgery outcome affecting up to a
third of the elderly patients, and it is associated with high morbidity and increased risk for …
third of the elderly patients, and it is associated with high morbidity and increased risk for …
Narrative review of systemic inflammatory response mechanisms in cardiac surgery and immunomodulatory role of anesthetic agents
W Maisat, K Yuki - Annals of Cardiac Anaesthesia, 2023 - journals.lww.com
Although surgical techniques and perioperative care have made significant advances,
perioperative mortality in cardiac surgery remains relatively high. Single-or multiple-organ …
perioperative mortality in cardiac surgery remains relatively high. Single-or multiple-organ …
Sedating mechanically ventilated COVID-19 patients with volatile anesthetics: insights on the last-minute potential weapons
A Suleiman, AB Qaswal, M Alnouti, M Yousef… - Scientia …, 2021 - mdpi.com
Coronavirus Disease 2019 (COVID-19) has spread globally with the number of cases
exceeding seventy million. Although trials on potential treatments of COVID-19 Acute …
exceeding seventy million. Although trials on potential treatments of COVID-19 Acute …
[HTML][HTML] The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain–Fas-associated death domain interaction
Sepsis remains a significant health care burden, with high morbidities and mortalities.
Patients with sepsis often require general anesthesia for procedures and imaging studies …
Patients with sepsis often require general anesthesia for procedures and imaging studies …
Volatile anesthetics affect macrophage phagocytosis
H Zha, E Matsunami, N Blazon-Brown… - PloS one, 2019 - journals.plos.org
Background Perioperative infections, particularly surgical site infections pose significant
morbidity and mortality. Phagocytosis is a critical step for microbial eradication. We …
morbidity and mortality. Phagocytosis is a critical step for microbial eradication. We …
[HTML][HTML] Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system
General anesthesia has been the requisite component of surgical procedures for over 150
yr. Although immunomodulatory effects of volatile anesthetics have been growingly …
yr. Although immunomodulatory effects of volatile anesthetics have been growingly …
[HTML][HTML] The use of volatile anesthetics as sedatives for acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) remains to pose a high morbidity and mortality
without any targeted therapies. Sedation, usually given intravenously, is an important part of …
without any targeted therapies. Sedation, usually given intravenously, is an important part of …
Volatile anesthetic sevoflurane attenuates toll-like receptor 1/2 activation
Y Mitsui, L Hou, X Huang, KC Odegard… - Anesthesia & …, 2020 - journals.lww.com
BACKGROUND: Although immunomodulatory effects of anesthetics have been increasingly
recognized, their underlying molecular mechanisms are not completely understood. Toll-like …
recognized, their underlying molecular mechanisms are not completely understood. Toll-like …
CD11c regulates hematopoietic stem and progenitor cells under stress
Abstract β2 integrins are well-known leukocyte adhesion molecules consisting of 4
members: CD11a-d. Their known biological functions range widely from leukocyte …
members: CD11a-d. Their known biological functions range widely from leukocyte …