Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association

JW O'Sullivan, S Raghavan, C Marquez-Luna… - Circulation, 2022 - ahajournals.org
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

Migraine: a review on its history, global epidemiology, risk factors, and comorbidities

P Amiri, S Kazeminasab, SA Nejadghaderi… - Frontiers in …, 2022 - frontiersin.org
Migraine affects more than one billion individuals each year across the world, and is one of
the most common neurologic disorders, with a high prevalence and morbidity, especially …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Adverse childhood experiences and adult mental health outcomes

HB Daníelsdóttir, T Aspelund, Q Shen… - JAMA …, 2024 - jamanetwork.com
Importance Exposure to adverse childhood experiences (ACEs) has consistently been
associated with multiple negative mental health outcomes extending into adulthood …

IMI risk factors for myopia

IG Morgan, PC Wu, LA Ostrin… - … & visual science, 2021 - iovs.arvojournals.org
Risk factor analysis provides an important basis for develo** interventions for any
condition. In the case of myopia, evidence for a large number of risk factors has been …

Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management

M Berk, O Köhler‐Forsberg, M Turner… - World …, 2023 - Wiley Online Library
Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Gene–environment correlations across geographic regions affect genome-wide association studies

A Abdellaoui, CV Dolan, KJH Verweij, MG Nivard - Nature genetics, 2022 - nature.com
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

Small effects: The indispensable foundation for a cumulative psychological science

FM Götz, SD Gosling… - … on psychological science, 2022 - journals.sagepub.com
We draw on genetics research to argue that complex psychological phenomena are most
likely determined by a multitude of causes and that any individual cause is likely to have …

Migraine: disease characterisation, biomarkers, and precision medicine

M Ashina, GM Terwindt, MAM Al-Karagholi, I De Boer… - The Lancet, 2021 - thelancet.com
Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …

Polygenic risk scores: from research tools to clinical instruments

CM Lewis, E Vassos - Genome medicine, 2020 - Springer
Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …