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Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
Migraine: a review on its history, global epidemiology, risk factors, and comorbidities
Migraine affects more than one billion individuals each year across the world, and is one of
the most common neurologic disorders, with a high prevalence and morbidity, especially …
the most common neurologic disorders, with a high prevalence and morbidity, especially …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Adverse childhood experiences and adult mental health outcomes
Importance Exposure to adverse childhood experiences (ACEs) has consistently been
associated with multiple negative mental health outcomes extending into adulthood …
associated with multiple negative mental health outcomes extending into adulthood …
IMI risk factors for myopia
Risk factor analysis provides an important basis for develo** interventions for any
condition. In the case of myopia, evidence for a large number of risk factors has been …
condition. In the case of myopia, evidence for a large number of risk factors has been …
Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
M Berk, O Köhler‐Forsberg, M Turner… - World …, 2023 - Wiley Online Library
Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …
neurodegenerative disorders–experience substantially higher rates of major depressive …
Gene–environment correlations across geographic regions affect genome-wide association studies
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
Small effects: The indispensable foundation for a cumulative psychological science
We draw on genetics research to argue that complex psychological phenomena are most
likely determined by a multitude of causes and that any individual cause is likely to have …
likely determined by a multitude of causes and that any individual cause is likely to have …
Migraine: disease characterisation, biomarkers, and precision medicine
Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …
Polygenic risk scores: from research tools to clinical instruments
Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …
disorders have a polygenic genetic architecture and have enabled researchers to identify …