The biliverdin reductase (BVR) isozymes BVRA and BVRB are cell surface membrane
receptors with pleiotropic functions. This review compares, for the first time, the structural …

Introduction: The development of precision medicine requires advanced technologies to
address the multifactorial disease stratification and to support personalized treatments …

Chemical exposure of cells may damage biomolecules, cellular structures, and organelles
thereby jeopardizing cellular homeostasis. A multitude of defense mechanisms have …

Heme is one of the most abundant molecules in the body acting as the functional core of
hemoglobin/myoglobin involved in the O2/CO2 carrying in the blood and tissues, redox …

Histopathological diagnoses have been done in the last century based on hematoxylin and
eosin staining. These methods were complemented by histochemistry, electron microscopy …

Urological malignancies are a major cause of morbidity and mortality worldwide. Advances
in early detection, diagnosis, prognosis and prediction of treatment response can …

Today, pathologists face many challenges in defining the precise morphomolecular
diagnosis and in guiding clinicians to the optimal patients' treatment. To achieve this goal …

Background Human prostate cancers are highly heterogeneous, indicating a need for
various novel biomarkers to predict their prognosis. Lipid metabolism affects numerous …

High-resolution matrix-assisted laser desorption/ionization imaging mass spectrometry (HR-
MALDI-IMS) is an emerging application for the comprehensive and detailed analysis of the …

Fast, selective, and noninvasive reporting of intracellular cancer-associated events and
species will lead to a better understanding of tumorigenesis at the molecular level and …