Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

Abstract Cytosolic calcium ([Ca2+] i) oscillations are a nearly universal mode of signalling in
excitable and non-excitable cells,,,. Although Ca2+ is known to mediate a diverse array of …

As the sole Ca2+ entry mechanism in a variety of non-excitable cells, store-operated calcium
(SOC) influx is important in Ca2+ signalling and many other cellular processes,,. A calcium …

IN many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+
influx across the plasma membrane1–3. The sustained entry of Ca2+ is thought to result …

Mammalian homologues of the Drosophila transient receptor potential (TRP) channel gene
encode a family of at least 20 ion channel proteins. They are widely distributed in …