Anatomy of four human Argonaute proteins

K Nakanishi - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene
expression post-transcriptionally. These non-coding regulatory RNAs become functional …

Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis

H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …

The evolutionary journey of Argonaute proteins

DC Swarts, K Makarova, Y Wang, K Nakanishi… - Nature structural & …, 2014 - nature.com
Argonaute proteins are conserved throughout all domains of life. Recently characterized
prokaryotic Argonaute proteins (pAgos) participate in host defense by DNA interference …

Structural basis for target-directed microRNA degradation

J Sheu-Gruttadauria, P Pawlica, SM Klum, S Wang… - Molecular cell, 2019 - cell.com
MicroRNAs (miRNAs) broadly regulate gene expression through association with Argonaute
(Ago), which also protects miRNAs from degradation. However, miRNA stability is known to …

Structural basis for microRNA targeting

NT Schirle, J Sheu-Gruttadauria, IJ MacRae - Science, 2014 - science.org
MicroRNAs (miRNAs) control expression of thousands of genes in plants and animals.
miRNAs function by guiding Argonaute proteins to complementary sites in messenger RNAs …

From guide to target: molecular insights into eukaryotic RNA-interference machinery

JJ Ipsaro, L Joshua-Tor - Nature structural & molecular biology, 2015 - nature.com
Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent,
specific and ubiquitous means of gene regulation. Through a number of pathways that are …

A dynamic search process underlies microRNA targeting

SD Chandradoss, NT Schirle, M Szczepaniak… - Cell, 2015 - cell.com
Argonaute proteins play a central role in mediating post-transcriptional gene regulation by
microRNAs (miRNAs). Argonautes use the nucleotide sequences in miRNAs as guides for …

Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins?

K Nakanishi - Wiley Interdisciplinary Reviews: RNA, 2016 - Wiley Online Library
RNA silencing is a eukaryote‐specific phenomenon in which microRNAs and small
interfering RNAs degrade messenger RNAs containing a complementary sequence. To this …

Structural foundations of RNA silencing by Argonaute

J Sheu-Gruttadauria, IJ MacRae - Journal of molecular biology, 2017 - Elsevier
Nearly every cell in the human body contains a set of programmable gene-silencing proteins
named Argonaute. Argonaute proteins mediate gene regulation by small RNAs and thereby …

Argonaute proteins: from structure to function in development and pathological cell fate determination

M Müller, F Fazi, C Ciaudo - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
The highly conserved Argonaute protein family members play a central role in the regulation
of gene expression networks, orchestrating the establishment and the maintenance of cell …