The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Penetrance is the probability that an individual with a pathogenic genetic variant develops a
specific disease. Knowing the penetrance of variants for monogenic disorders is important …

The state of somatic energy stores in metazoans is communicated to the brain, which
regulates key aspects of behaviour, growth, nutrient partitioning and development. The …

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and
depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight …

The melanocortin action is well perceived for its ability to regulate body weight
bidirectionally with its gain of function reducing body weight and loss of function promoting …

Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein)
gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme …

Introduction Heterozygous variants in the leptin-melanocortin pathway are associated with
obesity. However, their effect on the long-term outcomes after Roux-en-Y gastric bypass …

Obesity derives from impaired central control of body weight, implying interaction between
environment and an individual genetic predisposition. Genetic obesities, including …

Obesity is a multifactorial and complex disease that often manifests in early childhood with a
lifelong burden. Polygenic and monogenic obesity are driven by the interaction between …

Liver X receptor-α (LXRα) regulates cellular cholesterol abundance and potently activates
hepatic lipogenesis. Here we show that at least 1 in 450 people in the UK Biobank carry …