Click chemistry: 1, 2, 3‐triazoles as pharmacophores

SG Agalave, SR Maujan… - Chemistry–An Asian …, 2011 - Wiley Online Library
Abstract The copper (I)‐catalyzed 1, 2, 3‐triazole‐forming reaction between azides and
terminal alkynes has become the gold standard of 'click chemistry'due to its reliability …

Activity-based proteome profiling of potential cellular targets of orlistat− an FDA-approved drug with anti-tumor activities

PY Yang, K Liu, MH Ngai, MJ Lear… - Journal of the …, 2010 - ACS Publications
Orlistat, or tetrahydrolipstatin (THL), is an FDA-approved antiobesity drug with potential
antitumor activities. Cellular off-targets and potential side effects of Orlistat in cancer …

In situ “click” assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups

M Hu, J Li, S Q. Yao - Organic letters, 2008 - ACS Publications
In Situ “Click” Assembly of Small Molecule Matrix Metalloprotease Inhibitors Containing Zinc-Chelating
Groups | Organic Letters Recently Viewedclose modal ACS ACS Publications C&EN CAS Find …

The use of click chemistry in the emerging field of catalomics

KA Kalesh, H Shi, J Ge, SQ Yao - Organic & Biomolecular Chemistry, 2010 - pubs.rsc.org
Of the thousands of known chemical reactions, a handful of reactions, called “click”
reactions, stand out with features such as good chemoselectivity, good solvent …

Click reactions meet flow chemistry: An overview of the applications of click chemistry under continuous flow conditions

N Kánya, TS Zsigmond, T Hergert… - … Process Research & …, 2023 - ACS Publications
Click reactions are versatile tools in the hands of synthetic chemists and materials scientists
around the world. Coupling click chemistry with the advantages and convenience of …

Conformational and supramolecular properties of main chain and cyclic click oligotriazoles and polytriazoles

HF Chow, KN Lau, Z Ke, Y Liang, CM Lo - Chemical Communications, 2010 - pubs.rsc.org
This Feature Article gives a summary on the conformational and supramolecular properties
of a special type of click molecules, namely, main chain and cyclic oligo-and polytriazoles …

[PDF][PDF] Synthesis of calixarene-based cavitands and nanotubes by click chemistry

J Morales-Sanfrutos, M Ortega-Munoz… - The Journal of Organic …, 2008 - academia.edu
Supramolecular chemistry has developed into a major research field since the syntheses
and complexation properties of the first crown ethers, cryptands, and spherands were …

High-Throughput Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (MptpB) Inhibitors Using Click Chemistry

LP Tan, H Wu, PY Yang, KA Kalesh, X Zhang… - Organic …, 2009 - ACS Publications
A∼ 3500-member library of bidentate inhibitors against protein tyrosine phosphatases
(PTPs) was rapidly assembled using click chemistry. Subsequent high-throughput screening …

Alkyne–Azide Cycloadditions with Copper Powder in a High‐Pressure Continuous‐Flow Reactor: High‐Temperature Conditions versus the Role of Additives

SB Ötvös, IM Mándity, L Kiss… - Chemistry–An Asian …, 2013 - Wiley Online Library
A safe and efficient flow‐chemistry‐based procedure is presented for 1, 3‐dipolar
cycloaddition reactions between organic azides and acetylenes. This simple and …

Click multivalent heterogeneous neoglycoconjugates–modular synthesis and evaluation of their binding affinities

M Ortega‐Muñoz, F Perez‐Balderas… - 2009 - Wiley Online Library
The efficient synthesis of structurally diverse, multivalent, heterogeneous
neoglycoconjugates by means of a series of different click‐based strategies is described …