[HTML][HTML] Nanopore sequencing technology, bioinformatics and applications
Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …
molecules have led to substantial improvements in accuracy, read length and throughput …
Testing at scale during the COVID-19 pandemic
Assembly and publication of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) genome in January 2020 enabled the immediate development of tests to detect the …
CoV-2) genome in January 2020 enabled the immediate development of tests to detect the …
Outbreak. info genomic reports: scalable and dynamic surveillance of SARS-CoV-2 variants and mutations
In response to the emergence of SARS-CoV-2 variants of concern, the global scientific
community, through unprecedented effort, has sequenced and shared over 11 million …
community, through unprecedented effort, has sequenced and shared over 11 million …
Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool
The response of the global virus genomics community to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic has been unprecedented, with significant …
syndrome coronavirus 2 (SARS-CoV-2) pandemic has been unprecedented, with significant …
The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology
The current coronavirus disease 2019 (COVID-19) pandemic is the first to apply whole-
genome sequencing near to real time, with over 2 million severe acute respiratory syndrome …
genome sequencing near to real time, with over 2 million severe acute respiratory syndrome …
Clinical metagenomics
CY Chiu, SA Miller - Nature Reviews Genetics, 2019 - nature.com
Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …
Zika virus infection enhances future risk of severe dengue disease
LC Katzelnick, C Narvaez, S Arguello… - Science, 2020 - science.org
The Zika pandemic sparked intense interest in whether immune interactions among dengue
virus serotypes 1 to 4 (DENV1 to-4) extend to the closely related Zika virus (ZIKV). We …
virus serotypes 1 to 4 (DENV1 to-4) extend to the closely related Zika virus (ZIKV). We …
Field-deployable viral diagnostics using CRISPR-Cas13
Mitigating global infectious disease requires diagnostic tools that are sensitive, specific, and
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK …
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK …
Nextstrain: real-time tracking of pathogen evolution
Understanding the spread and evolution of pathogens is important for effective public health
measures and surveillance. Nextstrain consists of a database of viral genomes, a …
measures and surveillance. Nextstrain consists of a database of viral genomes, a …
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection
The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …