Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

Recent years have witnessed a revolution in our understanding of microglia biology,
including their major role in the etiology and pathogenesis of neurodegenerative diseases …

Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis
of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …

Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells
(GSC). Pan-cancer analyses have revealed that stemness of cancer cells correlates …