Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells.
Invasion is a conserved process that relies on the timely and spatially controlled exocytosis …

Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a
central role in the establishment of parasitism. The rhoptry content includes membranous as …

Examining host–pathogen interactions in animals can capture aspects of infection that are
obscured in cell culture. Using CRISPR-based screens, we functionally profile the entire …

The malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within
an intact nuclear envelope, and differs significantly from its human host. Mitosis is …

Apicomplexan parasites secrete contents of the rhoptries, club-shaped organelles in the
apical region, into host cells to permit their invasion and establishment of infection. The …

Cellular factors have important roles in all facets of the flavivirus replication cycle.
Deciphering viral-host protein interactions is essential for understanding the flavivirus life …

The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+
homeostasis in malaria parasites and has been implicated in the mechanism of action of …

Apicomplexan parasites are unicellular eukaryotes that invade the cells in which they
proliferate. The development of genetic tools in Toxoplasma, and then in Plasmodium, in the …

Malaria is a dangerous disease that contributes to millions of hospital visits and hundreds of
thousands of deaths, especially in children residing in sub-Saharan Africa. Although several …

Within a host, pathogens encounter a diverse and changing landscape of cell types,
nutrients, and immune responses. Examining host-pathogen interactions in animal models …