Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …

Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

Cellular metabolism regulates immune cell activation, differentiation and effector functions,
but current metabolic approaches lack single-cell resolution and simultaneous …

Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …

Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be
associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived …

Bone regeneration is a highly synchronized process that requires multiple biochemical,
bioelectrical, mechanical, and other physiological cues. The restoration and delivery of …