Abstract The Electron Microscopy Data Bank (EMDB) is the global public archive of three-
dimensional electron microscopy (3DEM) maps of biological specimens derived from …

Drug action is inherently multiscale: it connects molecular interactions to emergent
properties at cellular and larger scales. Simulation techniques at each of these different …

Public archiving in structural biology is well established with the Protein Data Bank (PDB;
wwPDB. org) catering for atomic models and the Electron Microscopy Data Bank (EMDB; …

Cryo-electron tomography (CET) utilizes a combination of specimen cryo-fixation and multi-
angle electron microscopy imaging to produce three-dimensional (3D) volume …

Abstract The European Bioinformatics Institute (EMBL-EBI) supports life-science research
throughout the world by providing open data, open-source software and analytical tools, and …

The 'cardiosphere'is a 3D cluster of cardiac progenitor cells recapitulating a stem cell niche-
like microenvironment with a potential for disease and regeneration modelling of the failing …

Recent advances in computational approaches and their integration into structural biology
enable tackling increasingly complex questions. Here, we discuss several key areas …

Electron cryo-microscopy (cryo-EM) is increasingly being used to determine 3D structures of
a broad spectrum of biological specimens from molecules to cells. Anticipating this progress …

Segmentation helps interpret imaging data in a biological context. With the development of
powerful tools for automated segmentation, public repositories for imaging data have added …