A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …

A flexible statistical framework is developed for the analysis of read counts from RNA-Seq
gene expression studies. It provides the ability to analyse complex experiments involving …

Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

RNA sequencing (RNA-seq) has been rapidly adopted for the profiling of transcriptomes in
many areas of biology, including studies into gene regulation, development and disease. Of …

Experimental variance is a major challenge when dealing with high-throughput sequencing
data. This variance has several sources: sampling replication, technical replication …

Background Finding genes that are differentially expressed between conditions is an
integral part of understanding the molecular basis of phenotypic variation. In the past …

RNA-Seq is a powerful tool for the study of alternative splicing and other forms of alternative
isoform expression. Understanding the regulation of these processes requires sensitive and …

There is abundant variation in gene expression between individuals, populations, and
species. The evolution of gene regulation and expression within and between species is …

Abstract Changes in gene expression are thought to underlie many of the phenotypic
differences between species. However, large-scale analyses of gene expression evolution …