Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
LB Ivashkiv - Nature Reviews Immunology, 2018 - nature.com
IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …
Chemokines and chemokine receptors: positioning cells for host defense and immunity
JW Griffith, CL Sokol, AD Luster - Annual review of immunology, 2014 - annualreviews.org
Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …
of all immune cells. Although chemokines were initially appreciated as important mediators …
Epidemiology, pathophysiology, diagnosis, and management of cerebral toxoplasmosis
Toxoplasma gondii is known to infect a considerable number of mammalian and avian
species and a substantial proportion of the world's human population. The parasite has an …
species and a substantial proportion of the world's human population. The parasite has an …
The immunobiology of the interleukin-12 family: room for discovery
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
[HTML][HTML] Development and maintenance of regulatory T cells
N Ohkura, Y Kitagawa, S Sakaguchi - Immunity, 2013 - cell.com
Regulatory T (Treg) cells are a developmentally and functionally distinct T cell
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …
Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …
heterogeneity reflecting the diverse environments and target cells that they regulate. To …
Continuous requirement for the TCR in regulatory T cell function
Foxp3+ regulatory T cells (Treg cells) maintain immunological tolerance, and their deficiency
results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen …
results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen …
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17
subset of helper T cells remain unclear. Here we used a novel strategy for the conditional …
subset of helper T cells remain unclear. Here we used a novel strategy for the conditional …