The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

The generation of neurons from stem cells involves the activity of proneural basic helix-loop-
helix (bHLH) proteins, but the mechanism by which these proteins irreversibly commit stem …

Background: The pattern of somites is traced out by a mechanism involving oscillating gene
expression at the tail end of the embryo. In zebrafish, two linked oscillating genes, her1 and …

Expression of the Notch effector gene Hes1 is required for maintenance of neural
progenitors in the embryonic brain, but persistent and high levels of Hes1 expression inhibit …

Transcription of messenger RNAs (mRNAs) for Notch signaling molecules oscillates with 2-
hour cycles, and this oscillation is important for coordinated somite segmentation. However …

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …

Vertebrate segmentation requires a molecular oscillator, the segmentation clock, acting in
presomitic mesoderm (PSM) cells to set the pace at which segmental boundaries are laid …

Notch signaling is a conserved cell fate regulator during development and postnatal tissue
regeneration. Using skeletal muscle satellite cells as a model and through myogenic cell …

One of the most striking features of the human vertebral column is its periodic organization
along the anterior-posterior axis. This pattern is established when segments of vertebrates …