Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Squamous cell carcinoma of the head and neck (HNSCC) is a relatively common human
cancer characterized by high morbidity, high mortality, and few therapeutic options outside …

Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both
inherited high-penetrance mutations in BRCA2 (ref.), ATM, PALB2 (ref.), BRCA1 (ref.) …

Breast cancer is now globally the most frequent cancer and leading cause of women's
death. Two thirds of breast cancers express the luminal estrogen receptor-positive (ERα+) …

A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-
differentiation into the squamous lineage during disease progression. Here, we investigated …

Owing to improved early surveillance and advanced therapy strategies, the current death
rate due to breast cancer has decreased; nevertheless, drug resistance and relapse remain …

Abstract Increased microRNA-10b (miR-10b) expression in the cancer cells in pancreatic
ductal adenocarcinoma (PDAC) is a marker of disease aggressiveness. In the present study …

Abstract p53 and its related genes, p63 and p73 constitute the p53 gene family. While p53 is
the most frequently mutated gene in human tumors, p63 and p73 are rarely mutated or …

Our understanding of cancer and the key pathways that drive cancer survival has expanded
rapidly over the past several decades. However, there are still important challenges that …

Squamous cell carcinoma (SCC) is a treatment‐refractory tumour which arises from the
epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin …