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Morphogen rules: design principles of gradient-mediated embryo patterning
The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
Hedgehog signaling in cancer: a prospective therapeutic target for eradicating cancer stem cells
The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …
fundamental processes, including embryonic development and tissue homeostasis …
[HTML][HTML] METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma
ZW Zhang, X Teng, F Zhao, C Ma, J Zhang, LF ** of mammalian developmental disorders
Mouse models are a critical tool for studying human diseases, particularly developmental
disorders. However, conventional approaches for phenoty** may fail to detect subtle …
disorders. However, conventional approaches for phenoty** may fail to detect subtle …
[HTML][HTML] Cytoneme signaling provides essential contributions to mammalian tissue patterning
During development, morphogens pattern tissues by instructing cell fate across long
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
Morphogen gradient reconstitution reveals Hedgehog pathway design principles
In develo** tissues, cells estimate their spatial position by sensing graded concentrations
of diffusible signaling proteins called morphogens. Morphogen-sensing pathways exhibit …
of diffusible signaling proteins called morphogens. Morphogen-sensing pathways exhibit …
[HTML][HTML] Rethinking the cilia hypothesis of hydrocephalus
Dysfunction of motile cilia in ependymal cells has been proposed to be a pathogenic cause
of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in …
of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in …
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has
been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a …
been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a …